Yes. Blender is released under the GNU General Public License, and blender.org's license page says you can use it for any purpose, commercial work included.
Your renders and files
"What you create with Blender is your sole property," the license page says. That covers images, movie files, .blend files and other data files Blender can write.
Commercial use is named for artists, studios making animated films or VFX, game artists working on commercial games, scientists, and students in educational institutions. The page contrasts this with trial or "educational" versions of commercial software that forbid commercial work, and says the GPL means nobody can take that freedom away.
What the GPL does require
The GPL asks anyone who shares Blender, or a modified version of it, to share their modifications too. The freedoms it names: use Blender for any purpose, distribute it, study how it works and change it, and distribute changed versions.
The source code is licensed as GPL version 2 or later. Blender as a whole, and any binary you distribute, falls under GPL version 3 or later. Some parts are looser: the Cycles render engine is Apache 2.0. Libraries bundled inside Blender carry their own licenses, such as the Python License, Zlib, MIT and BSD.
Add-ons
Blender's Python API is part of the software, so the license page says Python scripts that are published must be shared under a GPL-compatible license. You may sell such scripts, but what you're selling is the download service; your customers get the script under the same GPL terms.
Internet and registration
Installing and using Blender needs no registration and makes no internet connection. Some bundled add-ons can reach the internet, aren't enabled on install, and ask permission when you turn them on. This applies to the official release from blender.org, and the page recommends using official releases.
Where the download is
blender.org/download lists version 5.2.3 LTS for Windows, Windows on Arm, macOS (Apple Silicon, macOS 13 or newer) and Linux, and also links a Steam build (as of Nov 9, 2026).